Inhibitory effect of Ad-Flk1-Fc on angiogenesis in bladder tumer
AIM:To investigate the inhibitory effect of Ad-Flk1-Fc on angiogenesis in bladder tumer.METHODS:Subcutaneous tumors were established in syngenic T 739 mice with B33739 cells.In each group,the mice were randomized and given PBS (vehicle control),2×10~9 PFU of Ad-Flk1-Fc(intratumoral injection,twice per week for 2 weeks).The gross volume of tumor were measured,the microvessel density(MVD)of tumorous tissues was observed using immunohistochemistry and pathological examination was conducted with light microscope.RESULTS:There was a significant difference in grossvolume,weight and MVD value of the tumor between the treatment and control group.CONCLUSION:Ad-Flk1-Fc can effectively inhibit the angiogenesis of bladder cancer in mice.
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