Expression and clinical significance of HER-2 in gastric cancer and metastastic lymph nodes
AIM:To investigate the expression of HER-2 in gastric cancer,Para-Cancerous Tissue and metastastic lymph nodes,explore its role and significance of the clinicopathology as well as prognosis,its correlation with lymph node metastasis and primary focus.METHODS:To examine expression of HER-2 on tissue microarray containing gastric normal mucosa(n=32),Para-Cancerous Tissue(n=54),metastastic lymph nodes(n=41),and gastric cancer(n=189)by immunohistochemistry.RESULTS:The positive rates for HER-2 of the gastric cancer paracancer and control were 68.8%.25.9%and 12.5%respectively,with significant difference among the three case groups(P＜0.05).In gastric cancer tissues,The positive rates of HER-2 protein were significantly associated with lymph node metastasis,depth of invasion,Lauren type,the degree of differentiation(P＜0.05),and not associated with sex,age,size of tumor(P＞0.05).The positive rates for HER-2 of the 41 gastric cancer and 41 metastastic lymph nodes were significantly different(P＜0.05).In metastastic lymph nodes,The positive rates for HER-2 is higher.Used Kaplan-Meier survival analysis,The survival time of patients with negative HER-2 was higher than those of patients with positive HER-2(P＜0.05),COX regression analys is showed that HER-2 expression was an independent prognostic factor of gastric cancer.CONCLUSION:The higher-expression of HER-2 is involved in occurring and development,invasion,metastasis of gastric cancer and a advanced incidents of gastric cancer.metastastic lymph nodes is heterogeneity that compared with primary tumors.HER-2 is a useful marker for predicting the outcome for patients with gastric cancer,and it is all independent prognostic indicator.
NETL
NSTL
万方数据
维普
