摘要
目的:探讨仙人掌果原汁及多糖提取物对实验性高脂血症大鼠血脂及脂质过氧化的影响.方法:选80只健康雄性SD大鼠,按血清总胆固醇(TC)水平随机选10只作为空白组,喂饲基础饲料;余70只为高脂造模型组,喂饲高脂饲料3wk,模型建立后,按TC水平随机分成7组(10只/组):模型组、果原汁低剂量组、果原汁中剂量组、果原汁高剂量组、果原汁多糖低剂量组、果原汁多糖高剂量组、洛伐他汀组,继续喂饲高脂饲料的同时,进行分组分剂量给药.结果:喂饲高脂饲料3 wk后,高脂造模型组血清TC,TG,LDL-C水平显著升高(P＜0.01)、HDL-C显著下降(P＜0.05);给药3 wk后,与模型组比较,各给药组TC,TG,LDL-C和apoB水平降低,有统计学差异(P＜0.05或P＜0.01),果原汁多糖高剂量组、洛伐他汀组HDL-C水平升高,有统计学差异(P＜0.05),各给药组apoA I水平升高,但无统计学差异;果原汁中剂量组、高剂量组、多糖低剂量组、高剂量组、洛伐他汀组SOD升高,有统计学差异(P＜0.05或P＜0.01),各给药组MDA降低,有统计学差异(P＜0.05或P＜0.01).结论:仙人掌果原汁及多糖提取物有明显的降血脂和抗氧化作用,应进一步加强其有效成份和作用机制的研究.
Abstract
AIM:To explore the effect of the cactus pear juice and its polysaccharide extract on the experiment hyperlipemia and lipid peroxidation.METHODS:According to the serum TC level,10 of 80 healthy male SD rat were randomly selected as control group which raised by basic animal feeds.The others were raised by hyper-fatty animal feeds for 3 weeks in order to established the hyperlipemia rat model.Seventy rats were divided into 7 groups randomly according to the serum TC(10/group):model group,low cactus pear juice group,middle cactus pear juice group,high cactus pear juice group,low polysaccharide group,high polysaccharide group,and lovastatin group.Continuing feeding hyper-fatty animal feeds,different doses were given separarely.RESULTS:The level of the serum TC,TG and LDL-C of rats raised by the hyper-fatty animal feeds for three weeks increased significantly(P＜0.01),while the level of the HDL-C decreased significantly(P＜0.05).When compared to the model group,the levels of the TC,TG,LDL-C and apoB decreased significantly(P＜0.01 or P＜0.05)in each group,while the level of the HDL-C increased significantly(P＜0.05)in high polysaccharide group and lovastatin group.The level of the apoA I increased without significant difference(P＞0.05).The level of the SOD increased significantly(P＜0.05 or P＜0.01)in the middle cactus pear juice group,high cactus pear juice group,low polysaccharide group,high polysaccharide group and lovastatin group 3 weeks later after administered.The level of the MDA decreased significantly(P＜0.05 or P＜0.01)in each group.CONCLUSION:The cactus pear juice and its polysaccharide have apparente effects on decreasing blood fat and antioxygen.We should study further into its active constituent and its mechanism.
基金项目
广西壮族自治区科学技术厅资助项目(桂科字0229035)
NETL
NSTL
维普
万方数据