Effect of phyllanthus emblica L on the expression of protein kinase B and glucose transporter4 mRNA in the skeletal muscle of insulin resistance rat
AIM:To observe Fmctus phyllanthi's effect on protein kinase B and glucose transporter 4(GLUT4)mRNA expression in insulin resistance(IR)rats by high fat diet.METHODS:Thirty male Wistar rats were randomly divided into the control group(n=10)which was given basic diet,and the model group(n=20)which was given high fat diet.After 6 weeks,the model group was randomly divided into 2 subgroups:insulin resistant group which continued to receive high fat diet.and a Fruetus Phyllanthi group which abide high fat diet at the same time to 2 mL dose of 3.5 g/kg weight Fructus Phyllanthi of gavage.the expression level of Protein kinase B and glucose transporter 4 in the skeletal muscle of rats were determined at the end of 12th week.RESULTS:Fructus Phyllanthi significantly improved insulin resistance,and the group of insulin resistance's protein kinase B and glucose transporter 4 expression significantly lower than the control group and Fructus Phyllanthi group,there was no significant difference between control group and Fructus Phyllanthi group.CONCLUSION:Fructus Phyllanthi significantly improved insulin resistance,and the reason may be related to increase protein kinase B and glucose transporter 4 expressions in the skeletal muscle.
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万方数据
维普
