Effects of Sinomenine on function of endothelial cells in medium with high concentration of glucose
AIM:To investigate the effect of Sinomenine on the expression of nitric oxid(NO),nuclear factor kappaB(NF-κB)and proliferation and apoptosis by high glucose in cultured humanumbilical vein endothelial cells(HUVEC).METHODS:HUVECs were isolated from freshly collected umbilical cords.Effect of SN at different concentration on the expression of NO,NF-κB and proliferation and apoptosis of HUVEC cultured with high glucose were observed.RESULTS:Compared with the control group,high glucose could inhibit the proliferation and induce apoptosis,and increase nuclear factor kappaB expression and decrease NO production of HUVECs.Sinomenine could increase the proliferation and decrease the apoptosis,and down nuclear factor kappaB expression and enhance NO production in HUVECs.CONCLUSION:Sinomenine could inhibit the endothelial dysfunction and apoptosis induced by high glucose.
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