Expression and analysis of CD44v6 and laminin in esophageal carcinoma
AIM:To investigate the expression of CD44v6 and laminin in esophageal carcinoma tissues and the relationship between the expression of CD44v6,laminin and the tumor invasion and metastasis.METHODS:CD44v6 and laminin expression was detected in normal esophageal mucosa,benign lesions,paracancerous tissues and primary tumor tissues with SP immunohistochemistal method.RESULTS:Compared with the normal esophageal mucosa,the expression of CD44v6 and laminin was significantly different in primary tumor tissues and benign lesions (P＜0.05).The expression of CD44v6 and laminin in tissues of normal esophageal mucosa was significantly different from that in paracancer,CD44v6 and laminin expression was closely correlated with the tumor grade and lymphatic metastasis in esophageal carcinoma(P＜0.05).The presence of CD44v6 and laminin expression has no relation to the clinical stage of the disease.There was no correlation between the expressions of CD44v6 and laminin(P＞0.10).CONCLUSION:The expression of CD44v6 and laminin maybe play an important role in the malignant transformation,invasion and metastasis of esophageal carcinoma.
NETL
NSTL
万方数据
维普
