摘要
目的:探讨血清肿瘤标志物对肺癌的诊断价值.方法:用电化学发光免疫法检测254例肺癌患者和88例肺良性疾病患者血清中癌胚抗原(CEA)、细胞角质素片断抗原(CYFRA21-1)和神经元特异性烯醇酶(NSE)的水平.结果:肺癌组3种肿瘤标志物水平均明显高于肺良性疾病组(P＜0.01),其中血清CEA对肺癌的诊断能力最大.这3种血清肿瘤标志物在肺癌的不同病理类型、临床分期及分化程度之间均有不同程度的差异.联合检测时,诊断灵敏度、特异度、正确率和约登指数(YI)可显著提高.结论:3种血清肿瘤标志物单个检测对肺癌的诊断价值有限,联合检测可显著提高肺癌的诊断正确率.
Abstract
AIM:To explore diagnostic value of serum tumor markers for lung cancer.METHODS:The value of three kinds of serum tumor markers,including carcino-embryonic antigen (CEA),cytokeratin fragment antiogen 21-1(CYFRA21-1)and neurone specific enolase(NSE),was detected in 254 patients with lung cancer and 88 patients with benign lung disease using electrochemiluminescence immunoassay(ECLIA).RESULTS:The level of the three kinds of serum tumor markers in lung cancer group were obviously higher than that in lung benign disease group (P＜0.01)and CEA had the best diagnostic ability for lung cancer.Among different pathologic types,clinical stages and differentiation,the three kinds of tumor markers had differences to certain extent.When the three tumor markers were combined,the sensitivity,correct rate and youden index(YI)were significantly increased.CONCLUSION:Single tumor marker had limited diagnostic value for lung cancer,while combination models could significantly increase the detection rate for lung cancer.
NETL
NSTL
维普
万方数据