Comparative study of diagnostic value of serum tumor markers for lung cancer
AIM:To explore diagnostic value of serum tumor markers for lung cancer.METHODS:The value of three kinds of serum tumor markers,including carcino-embryonic antigen (CEA),cytokeratin fragment antiogen 21-1(CYFRA21-1)and neurone specific enolase(NSE),was detected in 254 patients with lung cancer and 88 patients with benign lung disease using electrochemiluminescence immunoassay(ECLIA).RESULTS:The level of the three kinds of serum tumor markers in lung cancer group were obviously higher than that in lung benign disease group (P＜0.01)and CEA had the best diagnostic ability for lung cancer.Among different pathologic types,clinical stages and differentiation,the three kinds of tumor markers had differences to certain extent.When the three tumor markers were combined,the sensitivity,correct rate and youden index(YI)were significantly increased.CONCLUSION:Single tumor marker had limited diagnostic value for lung cancer,while combination models could significantly increase the detection rate for lung cancer.
NETL
NSTL
万方数据
维普
