Clinical significance of MEK1 expression in colorectal cancer tissues
AIM:To investigate expression of MEKl in colorectal cancer and its association with lymphatic and hepatic metastasis.METHODS:Immunohistochemistry was used to assay MEK1 expression in primary foci,normal colorectal mucosa,metastatic lymph modes and hepatic metastasis in 86 cases of colorectal cancer.RESULTS:The rates of MEK1 expression in primary foci,normal colon mucosa,lymphatic and hepatic metastasis were 52.3%,32.6%,71.4%,and 78.3%respectively.The positive rates of MEK1 in primary foci,lymphatic and hepatic metastasis were higher than that in normal mucosa(P＜0.01).According to TNM stage,the positive rate of MEK1 in stage Ⅲ and Ⅳ was higher than that in stage Ⅰ and Ⅱ(P＜0.01).And a higher rate of MEK1 expression was detected in low differentiation adenoearcinoma and mucus adenocarcinoma than in middle-high differentiation adenocarcinoma(P＜0.01).The accumulated three-year survival in group of MEK1 positive and negtive was 41.3%and 73.1%,respectively.And the difference between the groups was significant(P＜0.05).CONCLUSION:Enhanced expression of MEK1 in colorectal cancer was associated significantly with lymphatic and hepatic metastasis.Assaying MEK1 expression has a prognosic value for colorectal cancer patients.
NETL
NSTL
万方数据
维普
