Evaluation of depth of anaesthesia with midlatency auditory evoked potentials and stress in elderly patients
AIM:To compare the changes of midlatency auditory evoked potentials,hemodynamic and plasma eortisol concentrations in elderly patients during general anaesthesia,in order to evaluate the value of MLAEP and stress in elderly patients of depth of anaesthesia.METHODS:F0ny patients scheduled for selective upper abdominal surgery with general anesthesia were randomly divided into 2 groups,one group was the young(aged 20-55 years old),the other was the old(ages 60-81 years old),each with 20 cases.They were all ASA Ⅰ-Ⅱ,cardiac function Ⅰ-Ⅱ,and no endocrine disorders and hearing impairment.Intubating and ventilating to control breathing machine after induction,HR,MAP,the wave amplitude and latency of MLAEP were recorded when patients entered the operating room(TO),3 min after induction of anesthesia(T1),1 min after intubation (T2),2 min after skin incision(T3),after abdominal Commissioner(T4),and after extubation(T5).Meanwhile,3 ml blood samples were abtained from the right internal jugular vein at all time points,and measured plasma's CORT concentrations.RESULTS:After administration,two groups of patients'incubation period of Pa,Nb were extension,and the volatility of Pa/Na,Pa/Nb were reduced(P＜0.05);at TO,the Pa was longer in the old than in the young(P＜0.05).HR was statistical significant differences in 2 groups after administration when compared with previous adminstration(expect T2);at T5,HR was faster in the young than in the old(P＜0.05).Map at T1,T2,T3,T4 were slowly compared with previous administration(P＜0.05),and at T4,MAP was higher in the young than in the old(P＜0.05).CORT changed every time compared with previous administration (P＜0.05),but the 2 groups was no statistical significant dirrerences(P＞0.05).CONCLUSION:MLAEP combined with hemodynamics and plasma cortisol can effectively evaluate the depth of anesthesia in the elderly.
NETL
NSTL
万方数据
维普
