survivin,P21在人口腔扁平苔藓及口腔鳞癌中的表达
Expression of survivin and P21 in oral Lichen planus and oral squamous cell carcinoma
毛兰萍 1刘晓锦 1刘沛 1石爱梅1
作者信息
- 1. 郑州大学第一附属医院口腔科,河南,郑州,450052
- 折叠
摘要
目的:探讨凋亡抑制因子survivin,P21基因在口腔扁平苔藓(OLP)、口腔鳞状细胞癌(OSCC)中的表达意义及其关系.方法:采用免疫组化SP法检测26例正常口腔黏膜组织、40例糜烂型OLP组织及40例OSCC组织survivin,P21基因的表达,并分析其相关性.结果:survivin蛋白、P21蛋白在正常口腔黏膜组织、OSCC组织和糜烂型OLP组织中的表达差异均有显著性(P＜0.05).survivin蛋白与P21蛋白在三种组织中的表达呈正相关(r_s=0.658,P＜0.05).结论:survivin,P21与OLP向OSCC转变有关,它们在OSCC的发生发展中起重要作用.
Abstract
AIM:To study the expression of survivin,a member of inhibitor of apoptosis protein family,and P21 gene and their relationship with oral lichen planus(OLP)and oral squamous cell carcinoma(OSCC).METHODS:Immunohistochemical technique S-P was used to detect the expression of survivin and P21 protein in 40 cases of OSCC,40 cases of OLP tissues and 26 cases of normal oral mucosa,and their relationship was analyzed.RESULTS:The expression of survivin and P21 were significantly different in normal oral mucosa,OLP and OSCC tissues(P＜0.05).The expressions of survivin and P21 showed a positive correlation in three types of tissues(r_s=0.685).CONCLUSION:Survivin gene and P21 gene involve in the transformation of OLP to OSCC.Survivin gene and P21 gene are important in the development and progress of OSCC.
关键词
survivin/P21/口腔扁平苔藓/鳞状细胞癌/基因表达/癌变Key words
survivin/P21/oral lichen planus/oral Squamous cell carcinoma/gene expression/canceration引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据