Meta-analysis of high frequency oscillatory ventilation and conventional mechanical ventilation in the treatment of neonatal respiratory distress syndrome
AIM:To investigate the effect and safety of high frequency oscillatory ventilation(HFOV)and conventional mechanical ventilation(CMV)in neonates with the respiratory distress syndrome(RDS).METHODS:Meta analysis was used to evaluate the data extracted from 12 published papers.Combined Odds ratio(OR)and its 95% confidence interval were calculated.RESULTS:Compared to CMV,HFOV was found to improve pulmonary function(P＜0.05)and reduce the incidence of chronic lung disease(CLD)(P＜0.01).However,the use of HFOV resulted in an increase in intracranial hemorrhage(ICH)(P＜0.05)in infants with RDS.There was no difierence in the incidence of air leak induced by HFOV and CMV.CONCLUSION:HFOV is more benefical than CMV in its therapeutic effect on neonatal RDS and in its ability to reduce the incidence of CLD.This benefit may be offset by the increase in the occurrence of ICH when using this modality.
high frequency oscillatory ventilationrespiratory distress syndromeconventional mechanical ventilationMeta-analyses
NETL
NSTL
万方数据
维普
