New method for monitoring the cardiovascular function in invasive tail suspension rats
AIM: To establish an invasive tail suspension(TS) rats model, which offers real time monitoring of rats' cardiovascular parameters. METHODS: Ten Sprague Dawley rats were equally divided into 2 groups at random, the normal group and TS group. Having been followed implantation of radiotelemeter, before and after TS, all rats were monitored the blood pressure (BP), heart rate( HR), and ECG waveform et al. RESULTS: All rats' body weight were increased significantly the fourteenth day after surgery. The BP and HR values of TS rats increased during the first 5 min after TS, and fell down from 5 min to 5.5 h after TS. After 5.5 h, there were no significant changes. However, the BP values were higher than that before TS and that in normal group, while the HR values had no such changes. The RR interval values decreased during the first 5 min after TS, and increased to the same level that before TS and after 5 min TS. There were no significant changes during the following days. Besides, there were no significant changes on any of the physiological parameters in normal group rats. CONCLUSION: The implantable radiotelemetry system was suitable for monitoring the changes of cardiovascular parameters in TS rats. It was a reliable method for studying the changes of cardiovascular function coursed by weightlessness. These results have also provided important experimental foundation for further studies.
NETL
NSTL
万方数据
维普
