Research on association of beta-fibrinogen gene-249C/T and Bcl-1G/A polymorphisms and type of cerebral infarction
AIM: To explore the relation of Beta-fibrinogen( Fg) gene-249C/T and Bcl-IG/A polymorphisms, the Fg indexes of Fg concentration, molecular polymerized function and the type of cerebral infarction. METHODS: A case-control study was used to analyze 54 patients with main-trunk cerebral infarction( MCI) , 106 patients with penetrating cerebral infarction ( PCI) and 160 normal control; Gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism; All sample with empty stomach should be drawn venous blood on early morning to determine 4 biochemistry indexes and the parameters illustrated Fg molecular reactivity, such as: Fg concentration, fibrin monomer polymerize velocity ( FMPV ) , absorbance maximum ( Amax ) , FMPV/Amax; All sample were examined by trained interviewers. RESULTS: The frequency of A Bcl-1 allele, GA + AA genotype in the group of MCI were higher than that of normal control (P < 0. 05) , No distinction of the frequency of BB-249C/T's genotype and allele between MCI, PCI and normal control were found. In the group of MCI, Fg concentration and FMPV of BS-249C/T CT + TT genotype were (4. 04 ± 0. 88 ) g/L and ( 0. 72 ±0. 12 ) by turns, while these of CC genotype were(5. 01 ± 0. 43 ) g/L and (0. 83 ±0.06). Fg concentration and FMPV of BB-249C/T CT + TT genotype was lower than that of CC genotype ( P < 0. 05 ). In the group of normal control, Fg concentration of BBBcl-lG/A GA + AA genotype was(4. 03 ±0. 90) g/L, which was higher than GG genotype's Fg concentration that was ( 3. 69 ± 0. 95 ) g/L ( P < 0.05). In the group of PCI, FMPV of BBBcl-1 G/A GA + AA geno-type was(0.74 ±0.11) , which was higher than GG genotype's FMPV that was(0.69 ±0.11) (P < 0.05). CONCLUSION: BB-249C/T was probably the important sites of the function express of FMPV, BβBcl-1GA, AA genotype could induce PCI by increasing the function expression of fibrin monomer polymerize function.
fibrinogengene polymorphismsBB-249C/TBBBcl 1G/Acerebral infarction type
NETL
NSTL
万方数据
维普
