Effects of gastric bypass on carbohydrate and lipid metabolism in non-obese diabetic Goto-Kakizaki rats
AIM: To observe the effects of gastric bypass on carbohydrate and lipid metabolism in non-obese diabetic Goto-Kakizaki (GK) rate. METHODS: Eighteen male GK rats were randomly allocated into 3 groups; Roux-en-Y gastric bypass (RYGB) group, sham RYGB group (sham-RYGB) and pair-fed control group. Each group was monitored for fasting glucose, oral glucose tolerance and insulin as well as plasma levels of cholesterol, triglycerides, and free fatty acids on 1st, 2nd, 4th, 12th weeks, post-operatively. RESULTS: No significant differences were observed in food intake among all groups ( F = 1. 222, P = 0.322). Fasting blood glucose levels measured post operatively showed significant drop in RYGB group compared to two control groups (F = 10.064, P = 0.002 ) , and significant elevation of fasting insulin(F = 56.138,P =0.000) in RYGB group. On post-operative 4th and 12th weeks, OGTT performed showed significant reduction of the area under the curve ( AUC) of serum glucose ( F =4.738, P = 0. 016) ,and statistical difference was observed in comparison to control groups ( P = 0. 039, P = 0.028 ). Significant increase was observed in the area under the curve (AUC) of serum insulin ( F_(4 wk) =192. 112,P =0. 000; F_(12wk)=228. 284,P = 0.000). Post operative values of cholesterol, triglycerides, and free fatty acids in RYGB group were significantly lower than that of sham-RYGB and control group( P < 0.05 ). CONCLUSION: Roux-en-Y gastric bypass is very effective in down-regulation ofthe carbohydrate and lipid metabolism through the enhancement of insulin function in non-obese diabetic GK rats, and these effects are not associated with weight loss or lower food intake.
gastric bypass2 type diabetes mellitusanimalscarbohydrate metabolism, lipid metabolism
NETL
NSTL
万方数据
维普
