Effect of sports tonics in improving diastolic function of left ventricle diastole in kidney-yang deficiency model
AIM: To observe the improvement effects of sports tonics on left ventricle diastolic function of rabbits with kidney-yang deficiency. METHODS: Twenty-one rabbits were randomly divided into 3 groups, a treatment group( natural group) , a control group of kidney-yang deficiency ( model group ) , a group of treatment group of kidney-yang deficiency model with traditional Chinese medicine (TCM) (group TCM). The Changes of loading of diastolic function in rabbits according to injection of Normal saline into vein to increase the preload in the natural group, model group and TCM group were compared. RESULTS: After modeling, the increase of left ventricular end-diastolic pressure were found in model group ( P < 0.01) , but the maximal decrease rate of left ventricle pressure become slower, and the cardiac force loop IV and the total area ratio with loop body increased ( P < 0.01) ; in the process of increasing the pre-load, the above-mentioned diastolic capability index decreased interiorly, and come back entirely 5 min later. Clue; The left ventricular diastolic Resilience of rabbits in model group decreased, the diastolic power and diastolic speed also descended, and the stress ability repertory of left ventricular diastole was diminished. But in the TCM group, the left ventricular end-diastolic pressure,the maximal decrease rate of left ventricle pressure and the ratio with loop body, had no significant differences as compared with those in natural group. CONCLUSION:①The left ventricular diastole of rabbits in model group decreased accordingly, the diastolic power and diastolic speed also descended; ②The left ventricular diastolic Resilience of rabbits, the diastolic power and diastolic speed in TCM group decreased accordingly had no difference with the treatment group.③In the process of increasing the pre-load, theleft ventricular diastolic function of rabbits in group TCM could increase within 6 s, and retain steady until 10 min later after the vein injection, which keep the same changing current with the treatment group.
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NSTL
万方数据
维普
