p16,p53和Mad2在胃癌中的表达及临床病理学意义
Expression of pl6, p53 and Mad2 in gastric cancer and its clinicopathological significance
党冬梅 1杨建军 2王颖萍 3魏晓萍 4梁树辉5
作者信息
- 1. 延安大学医学院病原生物学教研室,陕西延安716000
- 2. 延安大学医学院属医院介入科,陕西延安716000
- 3. 延安大学医学院病理教研室,陕西延安716000
- 4. 延安大学医学院生理教研室,陕西延安716000
- 5. 第四军医大学西京医院消化科,陕西西安710033
- 折叠
摘要
目的:研究p16,p53和Mad2基因在胃癌中的表达及其临床病理学意义.方法:应用免疫组化SP法检测胃癌组和对照组(正常胃粘膜、慢性浅表性胃炎、慢性萎缩性胃炎、增生性息肉、不典型增生)中p16,p53和Mad2蛋白的表达.结果:对照组中p16,p53和Mad2的阳性率分别为74.6%,32.8%和59.7%,而胃癌中p16,p53和Mad2的阳性率分别为46.3%,58.7%和79.1%,各指标在两组间的表达均有显著性差异(P<0.05);p16在累及浆膜组的表达与未累及浆膜组间有显著性差异(P<0.05);p16,p53和Mad2在有淋巴结转移组与无淋巴结转移组间均存在显著性差异(P<0.05).结论:p16,p53和Mad2基因表达的异常在胃癌的发生、发展和预后中起着重要的作用.
Abstract
AIM: To study the p16, p53 and Mad2 gene expression in gastric cancer and its clinicopathological significance. METHODS: In gastric cancer group and control group (normal gastric mucosa, chronic superficial gastritis, chronic atrophic gastritis, hyperplastic polyp, atypical hyperplasia) , detect the p16, p53 and Mad2 protein expression with SP immu-nohistochemical method. RESULTS: The pl6, p53 and Mad2 positive rates were 74. 6% , 32. 8% and 59. 7% in the control group and 46. 3% , 58. 7% and 79. 1% in the gastric cancer group, the indicators in the two groups expression were significantly different (P < 0. 05 ); pl6 expression was a significant difference (P < 0. 05) in serosa involved group and not serosa involved group; pl6, p53 and Mad2 in the group with lymph node metastasis and lymph node metastasis group there are significant differences (P < 0. 05). CONCLUSION: The pl6, p53 and Mad2 gene abnormal expression play an important role in gastric cancer incidence, development and prognosis.
关键词
胃癌/p16/p53/Mad2Key words
gastric cancer/p16/p53/Mad2引用本文复制引用
基金项目
延安大学科研基金(YD2005-050)
延安大学科研基金(YDK2005-019)
延安大学科研基金(YDK2005-018)
出版年
2009
NETL
NSTL
维普
万方数据