首页|p16,p53和Mad2在胃癌中的表达及临床病理学意义

p16,p53和Mad2在胃癌中的表达及临床病理学意义

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目的:研究p16,p53和Mad2基因在胃癌中的表达及其临床病理学意义.方法:应用免疫组化SP法检测胃癌组和对照组(正常胃粘膜、慢性浅表性胃炎、慢性萎缩性胃炎、增生性息肉、不典型增生)中p16,p53和Mad2蛋白的表达.结果:对照组中p16,p53和Mad2的阳性率分别为74.6%,32.8%和59.7%,而胃癌中p16,p53和Mad2的阳性率分别为46.3%,58.7%和79.1%,各指标在两组间的表达均有显著性差异(P<0.05);p16在累及浆膜组的表达与未累及浆膜组间有显著性差异(P<0.05);p16,p53和Mad2在有淋巴结转移组与无淋巴结转移组间均存在显著性差异(P<0.05).结论:p16,p53和Mad2基因表达的异常在胃癌的发生、发展和预后中起着重要的作用.
Expression of pl6, p53 and Mad2 in gastric cancer and its clinicopathological significance
AIM: To study the p16, p53 and Mad2 gene expression in gastric cancer and its clinicopathological significance. METHODS: In gastric cancer group and control group (normal gastric mucosa, chronic superficial gastritis, chronic atrophic gastritis, hyperplastic polyp, atypical hyperplasia) , detect the p16, p53 and Mad2 protein expression with SP immu-nohistochemical method. RESULTS: The pl6, p53 and Mad2 positive rates were 74. 6% , 32. 8% and 59. 7% in the control group and 46. 3% , 58. 7% and 79. 1% in the gastric cancer group, the indicators in the two groups expression were significantly different (P < 0. 05 ); pl6 expression was a significant difference (P < 0. 05) in serosa involved group and not serosa involved group; pl6, p53 and Mad2 in the group with lymph node metastasis and lymph node metastasis group there are significant differences (P < 0. 05). CONCLUSION: The pl6, p53 and Mad2 gene abnormal expression play an important role in gastric cancer incidence, development and prognosis.

gastric cancerp16p53Mad2

党冬梅、杨建军、王颖萍、魏晓萍、梁树辉

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延安大学医学院病原生物学教研室,陕西延安716000

延安大学医学院属医院介入科,陕西延安716000

延安大学医学院病理教研室,陕西延安716000

延安大学医学院生理教研室,陕西延安716000

第四军医大学西京医院消化科,陕西西安710033

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胃癌 p16 p53 Mad2

延安大学科研基金延安大学科研基金延安大学科研基金

YD2005-050YDK2005-019YDK2005-018

2009

第四军医大学学报
第四军医大学

第四军医大学学报

CSTPCDCSCD北大核心
影响因子：0.599
ISSN：1000-2790
年,卷(期)：2009.30(23)
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