首页|GnRH-a对化疗大鼠生育功能保护作用的研究

GnRH-a对化疗大鼠生育功能保护作用的研究

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目的:探讨促性腺激素释放激素激动剂(GnRH-a)对化疗大鼠生殖功能的保护作用.方法:选用雌性SD大鼠40只随机分为四组,每组10只,腹腔注射,空白对照组(生理盐水1 mL/d,连续20 d),环磷酰胺组(生理盐水,连续10 d后CTX 20 mg/kg,连续10 d),醋酸曲谱瑞林组(GnRHa 5 μg溶于1 mL的生理盐水中,连续20 d),醋酸曲谱瑞林+环磷酰胺组(GnRHa 5μ溶于1 mL生理盐水中连续10 d后,GTX 20mg/kg连续10 d),给药后使雌鼠受孕,受孕20 d处死孕鼠观察各组孕鼠及其胎鼠的不同.结果:四个实验组中,环磷酰胺组胎鼠致死率与对照组比较差异显著(P<0.05);观察四个实验组胎鼠的内脏和骨骼未见明显畸形.结论:醋酸曲谱瑞林先于环磷酰胺运用可以降低仔鼠致死率,提示在保护卵巢功能的同时可能对于大鼠的生育能力也有一定得保护作用.
Protective effects of GnRH-a on reproductive function in chemotherapy-treated rat
AIM: To investigate the protection of gonadotropin-releasing hormone agonist (GnRH-a) on reproductive function in rats with chemotherapy. METHODS: Forty female SD rats were randomly divided into 4 groups, 10 rats per group,by intraperito-neal injection, blank control group, cyclophosphamide group, GnRHa group and GnRHa + CTX groups, after administration to make female conception. After pregnancy of 20 d, pregnant rats were sacrificed to observe the different of each group of pregnant mice and fetal rat. RESULTS: The four experimental group,fetal rats mortality of cyclophosphamide group compared with controls were significantly ( P < 0.05 ). Observation of the four experimental groups of the internal organs and no obvious skeletal malformations in fetal mice. CONCLUSION: Use Triptorelin prior to the cyclophosphamide can reduce mortality in rats, the protection of ovarian may be to rat fertility has certain protective effect.

GnRHacyclophosphamidereproductive functionprotective effect

龚照、辛晓燕、徐海燕、胡艳

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第四军医大学西京医院妇产科,陕西西安710033

醋酸曲谱瑞林 环磷酰胺 生殖功能 保护作用

2009

第四军医大学学报
第四军医大学

第四军医大学学报

CSTPCDCSCD北大核心
影响因子：0.599
ISSN：1000-2790
年,卷(期)：2009.30(23)
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