辛伐他汀对大鼠急性心肌梗死后心室重塑的保护作用
Protective effect of simvastatin against ventricular remodeling in postinfarction heart failure rats
苏菲菲 1郑强荪 1尚福军 1张军 2段云燕 2丁璐1
作者信息
- 1. 第四军医大学唐都医院心脏内科,陕西西安710038
- 2. 第四军医大学西京医院超声科,陕西西安710033
- 折叠
摘要
目的:研究在心肌梗死后辛伐他汀对钙调神经磷酸酶(CaN)的表达以及心室重塑的影响.方法:将SD大鼠随机分为假手术组、单纯模型组和辛伐他汀组,每组10只.用SD大鼠建立急性心肌梗死模型以致心衰.8 wk后测定左室质量指数,B超检测左室形态结构,Western Blot检测心肌CaN蛋白表达.结果:①单纯模型组和辛伐他汀组心肌肥厚指数明显高于假手术组,辛伐他汀组心肌肥厚指数明显低于单纯模型组(P<0.05).②单纯模型组和辛伐他汀组心肌CaN蛋白表达水平高于假手术组(P<0.05),辛伐他汀组低于单纯模型组(P<0.05).结论:辛伐他汀可能参与干预CaN介导的心肌肥厚通路从而改善心脏功能.
Abstract
AIM: To investigate the effects of simvastatin on calcineurin(CaN) expression and ventricular remodeling in rats with myocardial infarction. METHODS: Sprague-Dawley rats were randomly allocated into 3 groups; The sham-operated groups (n = 10) , model groups(n = 10) and simvastatin-treated groups (n = 10). The model of myocardial infarction was established in order to cause heart failure. At the end of the treatment period, the left ventricular weight/body weight ratio, left ventricular mass, wall thickness ( by echocardiography ) , myocardial content of CaN (by westernblot) were assessed. RESULTS: ① The left ventricular weight/body weight ratio of model group, as well as simvastatin-treated group, was significantly higher than sham-operated group(P <0. 05) ; compared with model group, the ratio was lower in simvastatin-treated group ( P < 0. 05 ). ② We observed a higher level of CaN expression in model group, as well as simvastatin-treated group, as compared to sham-operated group ( P < 0. 05 ) ; significant higher level of CaN expression was observed in model group compared to simvastatin-treated group ( P < 0.05). CONCLUSION:The present data suggest that simvastatin may inhibit calcineurin-mediated hypertrophy in rats with heart failure and improve heart function.
关键词
辛伐他汀/钙调神经磷酸酶/心肌梗死/心衰Key words
simvastatin/calcineurin/myocardial infarction/heart failure引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据