Protective effect of simvastatin against ventricular remodeling in postinfarction heart failure rats
AIM: To investigate the effects of simvastatin on calcineurin(CaN) expression and ventricular remodeling in rats with myocardial infarction. METHODS: Sprague-Dawley rats were randomly allocated into 3 groups; The sham-operated groups (n = 10) , model groups(n = 10) and simvastatin-treated groups (n = 10). The model of myocardial infarction was established in order to cause heart failure. At the end of the treatment period, the left ventricular weight/body weight ratio, left ventricular mass, wall thickness ( by echocardiography ) , myocardial content of CaN (by westernblot) were assessed. RESULTS: ① The left ventricular weight/body weight ratio of model group, as well as simvastatin-treated group, was significantly higher than sham-operated group(P <0. 05) ; compared with model group, the ratio was lower in simvastatin-treated group ( P < 0. 05 ). ② We observed a higher level of CaN expression in model group, as well as simvastatin-treated group, as compared to sham-operated group ( P < 0. 05 ) ; significant higher level of CaN expression was observed in model group compared to simvastatin-treated group ( P < 0.05). CONCLUSION:The present data suggest that simvastatin may inhibit calcineurin-mediated hypertrophy in rats with heart failure and improve heart function.
NETL
NSTL
万方数据
维普
