Significance of the alteration of Th3 in patients with acute coronary syndrome
AIM: To investigate the alteration and its significance of T help 3 cells ( Th3 ) in patients with acute coronary syndrome. METHODS: Ninty-one patients were divided into 4 groups: acute myocardial infarction( AMI, re =26) ,unstable angina ( UA, n =25) .stable angina(SA, n =22) and chest pain syndrome (CPS, n-18). The frequencies of Th3 in peripheral blood were detected by flow cytometric analysis. Th3-related plasma cytokine( TGF-β1 ) concentrations were measured by enzyme-linked immunosorbent assay ( ELISA ). RESULTS: The peripheral Th3 number and the levels of TGF-pl were found to significant lower in patients with ACS as compared with those in patients with stable angina and chest pain syndrome( P <0.01). The frequencies of Th3 ( CD4~+ TGF-β +/CD4~+ T cells) were markedly decreased in patients with AMI ( 2. 7 ± 1. 1 ) % and UA (2. 5 ± 0.9)% than those in patients with SA(4. 94 ± 1. 7)% and CPS (4.5 ± 1. 8 ) % ( P < 0. 01) , while there was no obvious difference between the SA group and the CPS group ( P > 0. 05 ). Th3 related cytokine TGF-β_1 markedly decreased in patients with AMI [TGF-β_1: (4. 84 ±2. 64)μg/L] and UA[TGF-β_1: (4. 39 ± 2.38 )μg/L] compared with patients with SA [ TGF-β_1: ( 7. 40 ± 4.22)μg/L] and CPS[ TGF-β1: (6.57 ± 3.76) μg/L]. Plasma concentration of TGF-β1 was positively correlated in 4 groups(r = 0.519, P < 0.01). CONCLUSION:The downregulation of Th3 cells in patients with acute coronary syndrome may play a potential role in plaque detabilization and the onset of ACS.
NETL
NSTL
万方数据
维普
