Clinical characteristics and Ser20Gly mutation screening of amylin gene in 234 diabetics with onset age less than 40 years
AIM: To study the clinical characters and the incidence of the amylin gene Ser20Gly mutation. METHODS: In 234 diabetic patients who onset diabetes before the age of 40 the parameters of the glucose and fat metabolism, anti-GAD antibody, the rate of diabetic family positive and insulin resistance were measured using routine methods. By PCR-RFLP plus direct sequencing to detect the mutation of the amylin gene Ser20Gly mutation. RESULTS: The FBG, PBG2h and TG of early onset diabetic patients were higher than the normal health group's. HbAlc was (10.4 ± 2. 4)%. HOMAIR was 3. 63-8. 60. The rate of GAD autoantibody positive was 3. 64%. There were more than 80% diabetic patients used diet and oral agent therapy. 18% of those patients used insulin treatment. Two patients have Ser20Gly mutation of amylin gene. One is a homozygous another one is heterozygous. CONCLUSION: There are severe insulin resistance and poor glucose control in the early onset diabetic patients. The prevalence of the amylin gene Ser20Gly mutation is 0. 85% in those early onset diabetic patients.
NETL
NSTL
万方数据
维普
