Bone mineral density of patients with growth hormone secreting pituitary adenomas
AIM: To evaluate the bone metabolic alteration of patients with growth hormone secreting pituitary adenoma ( CH adenoma) in Chinese mainland and further to investigate the relevant factors leading to the change of bone mineral density (BMD). METHODS: Twenty-three patients with GH adenoma (9 men and 14 women) and 244 healthy controls were enrolled in this study between December 2007 and July 2008 and the BMD of the patients were assessed. The hormonal activities of the preoper-ative patients were analyzed to reveal the influencing factors of BMD. RESULTS: The Z scores of BMD of the patients with GH adenoma were significantly higher than those of corresponding controls. Compared with the Z scores of male controls, the ones of male patients significantly increased. However, there was not a statistical difference of Z scores between female patients and its controls. Logistic regression analysis revealed that there was not a significant correlation between BMD of the patients and serum growth hormone. The mean Z score of hypogonadal group was lower than that of eugonadal group, but no statistical difference existed between them. CONCLUSION: The BMD of patient with GH adenoma often increases, and the interaction of multiple factors is involved in the change of BMD.
growth hormone secreting pituitary adenomasacro-megalybone mineral density
NETL
NSTL
万方数据
维普
