A new type of renal ischemical reperfusion injury mice model
AIM: To set up a new type of renal ischemia-reper-fusion injury mice model by controllable thread hanging method. METHODS: Three weeks-old C57BL/6J mice, weighed 20 g. thin thread was used to hung the renal artery only, and was connected with a 1 g standard weight passing through a slidewheel. RESULTS: After 45 min of ischemia and 24 h of reperfusion, serum BUN and Cre of were all increased above the level of those before ( P < 0.01). Histopathology also confirm the same change. CONCLUSION: This new type of IRI mice model has many benefits than those model types before. It can successfully model the course of renal ischemic-reperfusion, and is worthy to be widely recommended.
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NSTL
万方数据
维普
