Analysis of differential expressed proteins between pathological scars and normal skin
AIM:To use proteomics method find differential expressed proteins of two-dimensional gel electrophoresis(2-DE)profiles of human hypertrophic scar,keloid and normal skin tissue,and to provide a new method for therapy of human pathological scars.METHODS:To establish and analyze two-dimensional gel electrophoresis(2-DE)profiles of hypertrophic seals,and normal skin.Identified part of differential expression proteins and identifled by MALDI-TOF-MS.RESULTS:2-DE profiles of human hypertrophic scar,keloid and normal skin tissue were compared 9 differential expression protein sports were selected and 5 differential expression protein were identified;the proteins were:phosphatidylethanolamine-binding protein,fatty acid binding protein,type Ⅰ collagen.carboxy-propeptide of alpha Ⅲ procollagen,carboxy-propeptide of alpha Ⅰ procollagen.CONCLUSION:In this study,5 differential proteins among human hypertrophic scar,keloid and normal skin tissue were identified.It may provide a new therapy and method system for study of the pathogenesis mechanism of pathological scars.
pathological scarshypertrophic scarkeloidproteomicsdifferential expression protein
NETL
NSTL
万方数据
维普
