Protective effects and the mechanism of Rosuvastatin on type 2 diabetic rats
AIM:To study the protective effects and the mechanism of Rosuvastatin on type 2 diabetic rats.METHODS:Type 2 diabetes meUitus(T2DM)rat model wag copied by giving SD rats a low dose of STZ.T2DM rats were divided randomly into control group(group B,n=25),Rosuvastatin group(group C,n=25),normal group was build(group A,n=10).At the end of 14 weeks,the HWI,CVF were detected,ultrastruetttre of left ventricle were observed with electron microscopes.The protein expression of PPARct in myocardium was detected by immunohistochemical staining.RESULTS:In group B,DCM hearts demonstrated diabetic cardiomyopathy phenotype,HWI and CVF were higher than that in group A,cardiac muscle degeneration,focal necrosis and region adipocytes infiltrating could be observed.Foregoing changes in group C rats were more relieved than those in group B rats.The protein expression of PPARα in myocardium showed that the IDP of PPARct in group B was higher than in group A rats and the IDP in group C rats was higher than that in group B rats(P<0.01).CONCLUSION:Rosuvastatin based on TC lowering,elicits benefitial effects on cardiovascular diseases by increasing PPARα expression.
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维普
