Synergistic inhibitory effects of static magnetic fields and adriamycin on breast cancer cell line MCF-7 in vitro
AEM:To explore the synergistic effects of static magnetic fields(SMF)and adriamycin(ADM)on cell growth in human breast cancer cell MCF-7 in vitro.METHODS:The MCF-7 cells were exposed to SMF in combination with various concentrations of ADM for 24 h.To analyze SMF effects in cell growth,MTT assay,flow cytometry,fluorescence microscopy and Western Blot analysis were used.RESULTS:SMF exposure significantly enhanced the cell growth inhibition and apoptosis by ADM,in which cell cycle arrest,cleaved Caspase-3,and reactive oxygen species(ROS)increased.CONCLUSION:SMF(10 mT)could enhance the antitumor effects of ADM,and would be a possibility of comprehensive therapy for breast cancer.
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万方数据
维普
