大豆异黄酮对去势雄性大鼠腰椎和胫骨骺端骨小梁变化的影响
Effects of soy isoflavones on the trabecula of lumbar and tibial epiphyseal extremity in bilateral castrated male rats
赵静 1张哲鹏 2王辛 1陈健康 3于军 3曲萍 3张学策 3铁茹3
作者信息
- 1. 第四军医大学口腔医学系七队,陕西,西安,710033
- 2. 第四军医大学预防医学系一队,陕西,西安,710033
- 3. 第四军医大学基础部教学实验中心,陕西,西安,710033
- 折叠
摘要
目的:研究大豆异黄酮对骨质疏松的治疗效应.方法:24只雄鼠随机分假手术组(A组)、双侧睾丸去除术的去势组(B组),实施双侧睾丸去除术并用大豆异黄酮治疗组(C组).术后8 wk HE染色观察腰椎和胫骨骨小梁的组织学改变及大豆异黄酮作用.结果:A组相比,B组SD大鼠腰椎和胫骨骨小梁宽度变窄,骨小梁间距变宽,骨小梁占视野面积比降低,而且发生多处断裂,C组与B组比较发现其有所改善,并有新的软骨生成.结论:大豆异黄酮对双侧去势雄性SD大鼠的骨质疏松有一定的治疗作用.
Abstract
AIM:To investigate the therapeutic effects of soybean isoflavones on osteoperosis.METHODS:Twenty-four male rats were randomly assigned into 3 groups:group A,as the control,were implemented sham surgery on the bilateral testieular;group B were treated with bilateral testieular ablation;group C were animals with bilateral testieular ablation and treated with soybean Boflavones.After 8-week treatment,the rats were sacrificed and the the trabecula of lumbar and tibial epiphyseal extremity was observed and the percentage of trabecula was determined under microscope.RESULTS:Compared with group A,the trabecula of lumbar and tibial in group B were significantly narrow,and spaces between trabeeulas became markedly wider.Also,percentages of trabeculas under microscope visual field decreased,and trabeculas were frequently broken.However,osteoporosis denonstrated in group B Was significant ameliorated in group C with development of new cartilage.CONCLUSION:Soy isoflavones have therapeutic effects on osteoporosis in bilateral testieular-ablated rats.
关键词
去势雄鼠/腰椎/胫骨/骨小梁/大豆异黄酮/骨质疏松Key words
bilateral castration male/lumbar/tibial epiphyseal extremity/trabeeular bone/soy isoflavones/osteoporosis引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据