Effects of methoxychlor on bone loss (osteroporosis)in mice
AIM:To investigate the effects of methoxychlor (MXC)on bone loss(osteroporosis)in mice. METHODS:MXC was administrated to the mice at doses of 0(control), 50,100 and 200mg/(kg·d)via oral gavage for consecutive 14d,then mice were euthanized. The thymus, liver and the spleen were weighted separately; then observed the morphology of the effects of MXC on left femur. At the end, took the bone histomorphomerey, bone hydroxyproline(B-HOP)and bone calcium to make the measurement and comparison. RESULTS:Compared with normal control mice, three doses of MXC can induce the decrease of femoral bone weight and the short transverse diameter. Bone-hydroxyproline content decreased remarkably, so did the bone-Ca. The thymus of the mice were atrophy. CONCLUSION:Three dosages of retinoic acid in mice can induce osteoporosis with the lessening of bone mass.
NETL
NSTL
万方数据
维普
