Effect of different doses of cisatracurium on the stress response during tracheal intubation in patients undergoing neurosurgery
AIM:To observe the effect of cisatracurium on the stress response during tracheal intubation in patients undergoing neurosurgery and to evaluate the best dose of cisatracurium for induction. METHODS:Sixty patients scheduled for brain tumor resection were randomly assigned to 3 groups(S_1 , S_2 and S_3). All patients were aged 15-65 years, weighed 40-80 kg and with an ASA of Ⅰ-Ⅲ. General anesthesia was induced by 0.03-0.05 mg/kg of midazolam, 4 ug/kg of fentanyl, 1-2 mg/kg of propofol and different doses of cisatraeurium(0.15 mg/kg for S_1 , 0.20 mg/kg for S_2 and 0.30 mg/kg for S_3). Tracheal intuhation was done 5 rain later. The noninvasive blood pressure(SBP, DBP, MAP)and heart rate(HR)were recorded 2 min before induction(T_0,baseline), 1 min before intubation(T_1), 1, 3 and 5 min after intubation(T_2, T_3 and T_4). RESULTS:Tracheal intubation was done 5 min after induction in all patients. Intubation score was 1 in 47 patients(78.3%)and 2 in 13 patients(21.7%). Patients in group S_1 suffered a transient significant increase of BP and HR after intubation. Patients in group S2 showed a mild increase of BP and HR after intubation. However, no hemodynamic change was seen in patients of group S_3. CONCLUSION:0.3 mg/kg of cisatracurium for general anesthesia induction could alleviate the stress reponse induced by tracheal intubation and shorten the time to intubation, which is beneficial for patients undergoing brain tumor resection.
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NSTL
万方数据
维普
