Immunohistochemic expression of DACH1 and its clinical significance in papillary thyroid carcinoma
AIM:To explore the immunohistochemical expression of DACH1 in papillary thyroid carcinoma and its clinical significance. METHODS:DACH1 expression in 10 nodular goiters, and 30 papillary thyroid carcinomas were detected with SABC immunohistochemical method, and the relationship between DACH1 expression and clinicopathological characteristics were further analyzed. RESULTS:The immunohistochemic expression of DACHl in papillary thyroid carcinoma and goiter is orientated as the cytomembrane and cytoplasm. The positive rate of DACH1 is 76.7% in papillary thyroid carcinoma, notably higher than that in nodular goiter, later is 30%(P<0.01). The positive rate of expression of DACH1 protein in papillary thyroid carcinoma with lymph nodes metastasis was 89. 5%, while it was 54. 5% in group of without lymph nodes metastasis. The differences are significant(P<0.05). CONCLUSION:The DACH1 protein is immunohistochemic overpressed in papillary thyroid carcinoma.There is obvious relationship between the degree of infiltration and metastasis of lymph node, indicating that DACHI may play a role in the carcinogenesis and development of papillary thyroid carcinoma.
NETL
NSTL
万方数据
维普
