鼻咽癌组织中VEGF,TNF-α及其受体蛋白表达及相关性研究
Dependability of VEGF and TNF-α to its receptor protein in nasopharyngeal carcinoma
韦福依1
作者信息
- 1. 百色市人民医院,广西,百色,533000
- 折叠
摘要
目的:观察探讨VEGF,TNF-α及受体蛋白VEG-FR1,VEGFR2,P55,P75在鼻咽癌组织的表达情况及VEGF,TNF-α与其受体表达的相关父系.方法:采用组化免疫方法,对60例鼻咽癌组织标本进行染色,观察VEGF,TNF-α与其受体VEGFR1,VEGFR2,P55,P75阳性率及表达强度,并对VEGF,TNF-α与其受体VEGFR1,VEGFR2,P55,P-/5表达进行相关性分析.结果:鼻咽癌组织中VEGF,TNF-α及受体蛋白VEGFRl,VEGFR2,P55,P75鼻咽癌组织中过度表达,VEGF同VEGFItl表达呈正相关(r=0.440,P=0.010)、同VEGFR1表达呈正相关(r=0.440,P=0.010),TNF-α同P55表达呈正相关(r=0.442,P=0.002).结论:VEGF,TNF-α及受体蛋白VEGFRl,VEGFR2,P55,P75在鼻咽癌组织中过度表达,其可能通过VEGF、TNF-α与受体的相互调控在肿瘤的发展中发挥作用.
Abstract
AIM:To observe the expression of vascular endothelial growth factor, tumor necrosis factorα(TNF-α), vascular endothelial growth factor receptor-proteinum 1, vascular endotbeiial growth factor receptor-proteinum 2 ,tumor necrosis factor-α receptor-proteinum 5500 kD(P55)and tumor necrosis factor-α receptor-proteinum 7500 kD(P75)in nasopharyngeal carcinoma, and analyze dependability of those cell factor. METHODS:Sixty tissues of nasopharyngeal carcinoma were stained with immunizing histological chemistry way, expression of VEGF, TNF-α, VEGFRI, VEGFR2, P55, P75 were measured, and analysize the dependability. RESULTS:VEGF, TNF-α, VEGFR1, VEGFR2,P55 and P75 were expressed in tissues of nasopharyngeal carcinoma, there were positive dependability between VEGF and VEGFRI ,VEGF and VEGFR2, TNF-α and P55(r =0.442, P=0.002), VEGF and TNF-α. CONCLUSION:TNF-α, P55 and P75 had an over expression in tissues of nasopharyngeal carcinoma.VEGF and TNF-α maybe nasopharyngeal carcinoma to nasopharyngeal carcinoma by mutual control to receptor protein.
关键词
鼻咽肿瘤/血管生长因子/血管生长因子受体/肿瘤坏死因子-α/肿瘤坏死因子受体55/肿瘤坏死因子受体75Key words
vascular endothehal growth factor/vascular endothelial growth factor receptor/tumor necrosis factor α/tumor necrosis factor-α receptor-proteinum 55/tumor necrosis factor-or receptor-proteinum 75引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据