首页|经纤维支气管镜肺灌洗治疗慢性阻塞性肺疾病急性加重期的临床疗效及对肺功能和血气的影响

经纤维支气管镜肺灌洗治疗慢性阻塞性肺疾病急性加重期的临床疗效及对肺功能和血气的影响

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目的:观察经纤维支气管镜肺灌洗治疗慢性阻塞性肺疾病(COPD)的临床疗效及对肺功能和血气的影响.方法:2007-06/2009-06,COPD急性加重期患者104例随机分为观察组和对照组,各52例.观察组在常规治疗的基础上采用经纤维支气管镜肺灌洗治疗;对照组仅采用常规治疗.观察两组的临床疗效及对肺功能和血气的影响.结果:观察组的显效率、总有效率明显高于对照组,两组比较差异有统计学意义(P<0.05).与治疗前比较,两组治疗后临床症状评分明显降低(P<0.05);FNC,PEFR和FEV_1水平明显升高(P<0.05);PaO_2和SpO_2水平明显升高,PaCO_2水平明显降低,差异有统计学意义(P<0.05).观察组的临床症状评分、肺功能指标(FVC,PEFR和FEV_1)和血气指标(PaO_2,PaCO_2和SpO_2)明显优于同期对照组,两组比较差异有统计学意义(P<0.05).结论:经纤维支气管镜肺灌洗治疗慢性阻塞性肺疾病的疗效显著,能够明显改善患者的临床症状、肺功能和血气状态.
Clinical curative effect of lung lavage by bronchoscopy in treatment with acute exacerbation of chronic obstructive pulmonary disease and its impact on pulmonary function and blood gas
AIM:To observe the clinical curative effect of lung lavage by bronchoscopy in treatment with acute exacerbation of chronic obstructive pulmonary disease and its impaction on pulmonary function and blood gas. METHODS:From June 2007 to June 2009, 104 cases of COPD at acute exacerbation phase patients were randomly divided into 2 groups, control group with 52 cases was treated with normal therapy and observation group with 52 cases was treated with lung lavage by bronchoscopy. The effective rate, clinical symptom score, pulmonary function indexes and blood gas indexes between the 2 groups were compared.RESULTS:The excellence rates and total effective rates in observation group were both significantly higher than those in control group(P<0.05). Compared with pre-treatment, clinical symptom scores were significantly degrade(P<0.05), FVC, PEFR and FEV_1 were significantly increased(P<0.05), PaO_2 and SpO_2 were significantly increased(P <0.05), PaCO_2 were significantly degrade(P<0.05). Moreover, the improvement of clinical symptom score, pulmonary function indexes(FVC, PEFR and FEV_1)and blood gas indexes(PaO_2, PaCO_2 and SpO_2)in observation group were significantly better than those in control group (P<0.05). CONCLUSION:Lung lavage by bronchoscopy in the treatment of COPD at acute exacerbation phase can enhance clinical curative effect rates and improve clinical symptom, score pulmonary status and blood gas.

lung lavage by bronchoscopyacute exacerbation of chronic obstructive pulmonary diseaseclinical curative effectpulmonary functionblood gas

李奕、卓安山、冯琳、曾葭

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解放军第411医院呼吸内科,上海,200081

上海市瑞会医院集团闵行医院老年科,上海,201100

经纤维支气管镜肺灌洗 慢性阻塞性肺疾病急性加重期 疗效 肺功能 血气

2009

第四军医大学学报
第四军医大学

第四军医大学学报

CSTPCDCSCD北大核心
影响因子:0.599
ISSN:1000-2790
年,卷(期):2009.30(24)
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