Effects of percutaneous coronary intervention on kaliuretic peptide,plasma renin activity and atrial natriuretic peptide in elderly patients with acute myocardial infarction and heart failure
AIM:To investigate the levels of the Kaliuretic peptide(KP),Plasma Rennin activity(PRA)and Atrial natriuretic peptide(ANP)in patients with acute myocardial infarction(AMI)and heart failure,and to evaluate the beneficial effects of percutaneous coronary intervention(PCI)on the above variables.METHODS:We studied 60 elderly patients with AMI and Heart failure randomly treated with routine drugs(n=30)or additional PCI(n=30).The levels of plasma KP,PRA and ANP in above elderly patients with AMI and heart failure at the different period of the course and in 60 healthy humans were determined by radioimmunoassay.Simultaneously,the left ventricular ejective fraction(LVEF)of above patients were measured by 2D echoacardiography in properation and postoperation.RESULTS:Compared with control group,the levels of plasma KP,PRA and ANP in elderly patients with AMI and heart failure were significantly increased at each point during the course.There was a significantly negative correlation between KP,ANP and LVEF at 7 d after the treatment,and there were no significant differences of plasma KP level in elderly patients with AMI and heart failure compared with no heart failure of control group.The plasma level of KP,PRA and ANP were decreased more significantly in the PCI group than in the routine group(P<0.05).CONCLUSION:KP and ANP might play an important role in pathogenesis of AMI,and its level still had guided the treatment of AMI even after PCI therapy.PCI is effective to improve the prognosis of elderly patients with AMI and heart failure.