目的:通过观察糖尿病性心肌病患者的胰高血糖素样肽-1(GLP-1)与炎性因子的相关性,探讨其在糖尿病性心肌病发病机制中的作用.方法:测定50例糖尿病心肌病患者(实验组)和30例健康者(对照组)的血清GLP-1、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血压、空腹血糖、餐后2 h 血糖(2hPG)、空腹血清胰岛素(FINS),计算稳态模型评价胰岛素抵抗指数(HOMA-IR).结果:实验组空腹血糖、2hPG、收缩压、FINS、HOMA-IR、hsCRP、IL-6和TNF-α均显著高于对照组(P<0.05),血清GLP1 显著低于对照组(P<0.05);GLP-1水平与hs-CRP(r=0.556,P=0.002)和HOMA-IR(r=0.445,P=0.007)呈显著负相关.结论:糖尿病性心肌病的发生发展是GLP-1、炎性因子、胰岛素抵抗等多因素综合作用的结果.
Correlation between GLP-1 and CRP in patients with diabetic cardiomyopathy
AIM:To investigate the correlation between glucagon like peptides-1(GLP-1)and inflammatory cytokines and evaluate mechanism of diabetic cardiomyopathy.METHODS:Serum GLP-1,hyper sensitive C-reactive protein(hs-CRP),interleukin6(IL-6),tumor necrosis factor-α(TNF-α),blood pressure,fasting plasma glucose,2 h plasma glucose(2hPG),fasting serum insulin(FINS)and homeostasis model assessment insulin resistance(HOMA-IR)were measured in 50 patients with diabetic cardiomyopathy(experimental group)and 30 healthy persons(control group).RESULTS:Compared with control group,fasting plasma glucose,2hPG,systolic pressure,FINS,HOMA-IR,hs-CRP,IL-6 and TNF-α were significantly increased(P<0.05),while serum GLP-1 were reduced in experimental group(P<0.05);serum GLP-1 were negatively correlated with hs-CRP(r=0.556,P=0.1302)and HOMA-IR(r=0.445,P=0.007).CONCLUSION:The occurance and development of diabetic cardiomyopathy is decided by interrelation of GLP-1,inflammatory cytokines and insulin resistance.
diabetic cardiomyopathyglucagon like peptides-1hyper sensitive C-reactive protein
NETL
NSTL
万方数据
维普
