绝经期后妇女子宫内膜息肉中雌、孕激素受体表达特点及意义
Expression and significance of estrogen receptor and progesterone receptor in the endometrial polyps in postmenopausal women
张博 1王建 2张颖 2曹引丽3
作者信息
- 1. 渭南市中心医院妇产科,陕西,渭南,714000
- 2. 第四军医大学西京医院妇产科,陕西,西安,710033
- 3. 陕西省妇幼保健院,陕西,西安,710003
- 折叠
摘要
目的:通过研究绝经后妇女子宫内膜息肉雌激素受体(ER)和孕激素受体(PR)的表达探讨其可能的发生机制及临床意义.方法:运用免疫组织化学方法检测并行半定量分析,对70例诊断子宫内膜息肉的绝经后妇女的内膜息肉及其邻近内膜组织中ER,PR的表达,并选用20例正常绝经后妇女的子宫内膜组织作为对照.结果:子宫息肉组腺体和间质内PR呈低水平表达,并明显低于对照组(P<0.05),其余各组中ER的表达无明显差异.结论:绝经后妇女PR的异常表达在子宫内膜息肉的发生中起重要作用.
Abstract
AIM:To investigate the significance and possible mechanism of endometrial polyps(EP)in postmenopansal women by evaluating the expression and significance of estrogen receptor (EP)and progesterone receptor(PR).METHODS:Seventy postmenopausal women with EP,who were performed with endometrial biopsy and removing polyps,and 20 pestmenopausal women with normal endometrium(EM)were as control group.The expression of ER and PR were evaluated by immunohistochemical method using a semiquantitative analysis.RESULTS:Expression of PR in gland and stroma were significantly decreased in endometrial polyps(P<0.05).The difference in expressions of ER in all groups was not found.CONCLUSION:Our date suggests that abnormal expressions of PR may play a crucial role in the pathogenesis of the EP in postmenopausal women.
关键词
子宫内膜/息肉/雌激素受体/孕激素受体Key words
endomerium/endometrial polyps/estrogen receptor/progesterone receptor引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据