急性有机磷中毒患者TNF-α和IL-18的变化
Clinical significance of TNF-αand IL-18 in acute organophosphorus pesticid poisoning
涂艳阳 1王伯良 1付建芳 1曹义战 2仲月霞 1田小溪1
作者信息
- 1. 第四军医大学唐都医院急诊科,陕西,西安,710038
- 2. 第四军医大学西京医院内分泌科,陕西,西安,710033
- 折叠
摘要
目的:探讨肿瘤坏死因子-α(TNF-α)、白细胞介素-18(IL-18)在急性有机磷中毒中的临床意义.方法:选取我院收治既往健康的急性中毒患者42例,来院即刻抽取肘静脉血保存至同批测定,与20例健康对照组-同采用放射免疫方法测定血清中TNF-α,IL-18含量,并对TNF-α,IL-18分别与其白细胞总数做相关性分析.结果:急性药物中毒患者血清中TNF-α,IL-18含量均较正常对照组显著升高(P<0.01),病情愈重,TNF-α,IL-8含量愈高;死亡组患者血清中TNF-α,IL-18含量明显高于存活组,具有统计学差异(P<0.01);中毒患者TNF-α与其白细胞总数呈显著正相关,IL-18与其白细胞总数呈显著正相关.结论:TNF-α,IL-18可能参与了急性有机磷中毒的病理过程,并可作为反映病情、评估预后的血清学参考指标.
Abstract
AIM:To study the clinical significance of TNF-α and IL-18 in acute organophosphorus pesticid poisoning.METHODS:All acute drug poisoning cases enrolled were 42,who were all healthy before poisoning.Conserve the blood serum.Deploying radio immunoassay to determine the levels of TNF-α and IL-18.Compare the levels of TNF-α and IL-18 between poisoning group and health control group(20 cases),and compare the levels of TNF-α and IL-18 of poisoning cases of different prognosis.We dealed all the data of TNF-α,IL-18 and total white cell count with the method of liner regression and correlation analysis.RESULTS:The levels of TNF-α and IL-18 in poisoning group were higher than those of control group(P<0.01).The more severer was the patient's condition,the higher were the levels of TNF-α and IL-18.During the poisoning cases.the levels of TNF-α and IL-18 in death group is evident higher then those of survive group;and the levels of TNF-α and IL-18 were obviously related to total white cell count.CONCLUSION:TNF-α and IL-18 are the serology index to reflect the occurance and change of acute poisoning,they improve prognosis of patients of acute poisoning.
关键词
急性有机磷中毒/肿瘤坏死因子-α/白细胞介素-18Key words
acute organophosphorus pesticide poisoning/tumor necrosis factor-α/interleukin-18引用本文复制引用
基金项目
陕西省科学技术研究发展计划(社发公关-015)
出版年
2009
NETL
NSTL
维普
万方数据