儿童急性杂合性白血病前期全血细胞减少1例报告并文献复习
Children transient pancytopenia preceding hybrid acute leukemia:One case report and review of literature
秦兰 1单丽娟 1杜晓军 2李巍3
作者信息
- 1. 新疆医科大学附属中医院血液科,新疆,乌鲁木齐,830000
- 2. 新疆医科大学中医学院,新疆,乌鲁木齐,830000
- 3. 新疆医科大学曲阜市中医院,山东,曲阜,273100
- 折叠
摘要
目的:为了提高对儿童急性淋巴细胞白血病前期(Pre-ALL)全血细胞减少的认识,报告1例以全血细胞减少为前期表现的急性杂合性白血病(HAL)患儿临床资料并进行文献复习.方法:观察1例男性患儿,11岁,确诊HLA(T淋巴细胞和髓细胞杂合)8 wk前发生过渡性、可恢复的全血细胞减少,且微小病毒B19抗体阳性.经正规化疗后可完全缓解.结果:经1疗程正规化疗完全缓解,但1mo后骨髓复发.结论:Pre-ALL的免疫表型可以为HAL(T淋巴细胞和髓系细胞杂合),提示预后不良.
Abstract
AIM:To report the development of children transient pancytopenia preceding acute lymphoblastic leukemia(PreALL)in a case of Pre-ALL whose immunophenotype is coexpression of T lymphoid and myeloid markers.METHODS:A 11-year-old child suffered from transient pancytopenia,and developed hybrid acute leukemia(HAL).Whose diagnosis of HAL was preceded by a serologically confirmed Parvovirus B19(PB19)infection.RESULTS:After a transient complete remission to the initial therapy,the patient developed the overall relapse of HAL. CoNCLUSION:The immunophenotype of Pre-ALL may be coexpression of T lymphoid and myeloid markers and the prognosis is poor.
关键词
急性淋巴细胞白血病前期/全血细胞减少/急性杂合性白血病/微小病毒B19Key words
preceding acute lymphoblastic leukemia/pancytopenia/hybrid acute leukemia/parvovirus B19引用本文复制引用
出版年
2009
NETL
NSTL
维普
万方数据