首页|儿童急性杂合性白血病前期全血细胞减少1例报告并文献复习

儿童急性杂合性白血病前期全血细胞减少1例报告并文献复习

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目的:为了提高对儿童急性淋巴细胞白血病前期(Pre-ALL)全血细胞减少的认识,报告1例以全血细胞减少为前期表现的急性杂合性白血病(HAL)患儿临床资料并进行文献复习.方法:观察1例男性患儿,11岁,确诊HLA(T淋巴细胞和髓细胞杂合)8 wk前发生过渡性、可恢复的全血细胞减少,且微小病毒B19抗体阳性.经正规化疗后可完全缓解.结果:经1疗程正规化疗完全缓解,但1mo后骨髓复发.结论:Pre-ALL的免疫表型可以为HAL(T淋巴细胞和髓系细胞杂合),提示预后不良.
Children transient pancytopenia preceding hybrid acute leukemia:One case report and review of literature
AIM:To report the development of children transient pancytopenia preceding acute lymphoblastic leukemia(PreALL)in a case of Pre-ALL whose immunophenotype is coexpression of T lymphoid and myeloid markers.METHODS:A 11-year-old child suffered from transient pancytopenia,and developed hybrid acute leukemia(HAL).Whose diagnosis of HAL was preceded by a serologically confirmed Parvovirus B19(PB19)infection.RESULTS:After a transient complete remission to the initial therapy,the patient developed the overall relapse of HAL. CoNCLUSION:The immunophenotype of Pre-ALL may be coexpression of T lymphoid and myeloid markers and the prognosis is poor.

preceding acute lymphoblastic leukemiapancytopeniahybrid acute leukemiaparvovirus B19

秦兰、单丽娟、杜晓军、李巍

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新疆医科大学附属中医院血液科,新疆,乌鲁木齐,830000

新疆医科大学中医学院,新疆,乌鲁木齐,830000

新疆医科大学曲阜市中医院,山东,曲阜,273100

急性淋巴细胞白血病前期 全血细胞减少 急性杂合性白血病 微小病毒B19

2009

第四军医大学学报
第四军医大学

第四军医大学学报

CSTPCDCSCD北大核心
影响因子：0.599
ISSN：1000-2790
年,卷(期)：2009.30(24)
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