Analysis of Codon Bias on Tail Protein Genes of Phage vB-EcoP-Bp4
To understand the characteristics of codon usage in tail protein genes of phage vB-EcoP-Bp4 (i.e. Bp4).Genes gp10,gp1 1 and gp13 were analyzed for the codon usages among N4-like phage Bp4 and other five phages by bioinformatics softwares.The results showed that the patterns of codon usage in tail protein genes of phage Bp4 were substantially consistent with other 5 phages,A or U- ended codons were prefered. In the genes gp10,gp1 1 and gp13 of phage Bp4,14,17,and 1 6 kinds of high-frequency codons were identi-fied respectively except AUG(M)and UGG(W).The bias comparison and cluster analysis on tail protein genes among phage Bp4 and other 5 phages demonstrated that putative tail protein gene gp10 of Bp4 was most similar to ECBP1,tail fiber protein gene gp1 1 was most similar to EC1-UPM and PhAPEC5,while tail spike protein gp13 was most similar to ECBP1 and EC1-UPM.The codon usages of tail proteins were substantially consistent with the levels of homology,and the results will provide further guidance for the study of phage Bp4.
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