Progress on Effect of Ketosis on Immune Functions in Perinatal Cows
Hypernatremia and high free fatty acid (NEFA)hyperlipidemia are the main pathologic features of ketosis.The occurrence of ketosis is closely related to the oxidative stress in animals.Studies have shown that hyperaldosteronism and high NEFA hyperlipidemia affect the numbers and functions of lymphocytes, white blood cells and neutrophils in animals,so that the occurrence of ketosis reduces the immune function of dairy cows,and the risks of mastitis,placenta retention,endometritis and other perinatal disease in-crease,making a serious reduction in cow production performance and reproductive performance and huge economic losses in dairy industry.This paper reviewed the effects of dairy cow ketone disease on the im-mune functions of dairy cows and its mechanism,and provided the basis for further study on the relation-ship between ketosis and other perinatal diseases.