Zoonotic tuberculosis(zTB)is a significant bacterial infectious disease worldwide,posing a severe threat to human and animal health,as well as public health security.The body's microflora plays an active role in development,immune regulation,and metabolism.Research has shown that the microflora is closely linked to the occurrence,development,treatment,and vaccine immunity of zTB,making it a hot topic in many fields.The microbiota can regulate the zTB process directly or indirectly through various means,such as influencing microbiota homeostasis,metabolism,and immune regulation.The thesis reviews the latest re-search on microflora and zTB,focusing on the association and regulatory mechanisms of gut flora and lung flora with zTB infection.It analyses the influence of gut-lung axis crosstalk and microbiota metabolite on zTB and explores the potential value of regulating the host microbiota composition and functions in preven-ting and assisting in the treatment of zTB.The aim is to provide a theoretical basis and reference for the prevention and control of zTB.
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