摘要
传染性法氏囊病(IBD)是由传染性法氏囊病病毒(IBDV)引起的一种急性、高度传染性、免疫抑制的禽类疾病,给家禽养殖业造成巨大的经济损失,引起人们的广泛关注.目前许多科研工作者对IBDV进行了多方面的研究,发现IBDV感染和复制的分子机制很复杂.论文主要对IBDV蛋白和宿主蛋白及因子相互作用在感染和复制中的作用、IBDV感染宿主细胞受体结合位点、IBDV感染后调控宿主细胞因子和干扰素、细胞凋亡情况和影响病毒感染和复制的miRNAs、lncRNAs和circRNAs进行综述,为IBDV的进一步研究和IBD防控提供参考.
Abstract
Infectious bursal disease is an acute,highly contagious,immunosuppressive avian disease caused by infectious bursal disease virus which has resulted in significant economic losses to the poultry industry and garnered widespread attention.Currently,numerous researchers have conducted extensive investiga-tions on IBDV and have discovered that the molecular mechanism underlying IBDV infection and replica-tion is highly intricate.This article comprehensively examines the involvement of IBDV proteins,host pro-teins,and their interactions in the processes of infection and replication.Additionally,it explores the recep-tor binding sites of IBDV in host cells,as well as miRNAs,lncRNAs,and circRNAs that regulate host cyto-kines and interferon responses,cell apoptosis,following IBDV infection while influencing virus propagation.The findings presented herein serve as a valuable reference for further research on IBDV pathogenesis and contribute to its prevention and control.
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