动物营养(英文)2024，Vol.16Issue(1) ：251-266.DOI:10.1016/j.aninu.2023.12.001

Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms:A narrative review

Pengju Wang Lv-hui Sun Xu Wang Qinghua Wu Aimei Liu
动物营养(英文)2024，Vol.16Issue(1) ：251-266.DOI:10.1016/j.aninu.2023.12.001
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Effective protective agents against the organ toxicity of T-2 toxin and corresponding detoxification mechanisms:A narrative review

Pengju Wang 1Lv-hui Sun 2Xu Wang 3Qinghua Wu 4Aimei Liu1
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作者信息

  • 1. Hubei Key Laboratory of Diabetes and Angiopathy,Medicine Research Institute,Xianning Medical College,Hubei University of Science and Technology,Xianning 437100,China
  • 2. Hubei Hongshan Laboratory,College of Animal Science and Technology,Huazhong Agricultural University,Wuhan,430070,China
  • 3. National Reference Laboratory of Veterinary Drug Residues(HZAU)and MAO Key Laboratory for Detection of Veterinary Drug Residues,Huazhong Agricultural University,Wuhan,430070,China
  • 4. College of Life Science,Yangtze University,Jingzhou 434025,China
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Abstract

T-2 toxin is one of the most widespread and toxic fungal toxins in food and feed.It can cause gastro-intestinal toxicity,hepatotoxicity,immunotoxicity,reproductive toxicity,neurotoxicity,and nephrotoxi-city in humans and animals.T-2 toxin is physicochemically stable and does not readily degrade during food and feed processing.Therefore,suppressing T-2 toxin-induced organ toxicity through antidotes is an urgent issue.Protective agents against the organ toxicity of T-2 toxin have been recorded widely in the literature,but these protective agents and their molecular mechanisms of detoxification have not been comprehensively summarized.In this review,we provide an overview of the various protective agents to T-2 toxin and the molecular mechanisms underlying the detoxification effects.Targeting appropriate targets to antagonize T-2 toxin toxicity is also an important option.This review will provide essential guidance and strategies for the better application and development of T-2 toxin antidotes specific for organ toxicity in the future.

Key words

T-2 toxin/Organ toxicity/Protective agent/Detoxification mechanism

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基金项目

Doctoral Initiation Fund Project Grant(BK202315)

Medical Research Special Fund of Hubei University of Science and Technology(2022YKY17)

Hubei Provincial Natural Science Foundation Programme(2023AFB537)

出版年

2024
动物营养(英文)

动物营养(英文)

CSTPCD
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