首页|Effect of red clover isoflavones on hormone,immune,inflammatory,and plasma biochemistry in lactating dairy cows

Effect of red clover isoflavones on hormone,immune,inflammatory,and plasma biochemistry in lactating dairy cows

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This study was to conducted to investigate the effect of red clover isoflavones on the health indicated by immune status and blood biochemistry in dairy cows.Sixty-eight healthy Holstein lactating cows were randomly divided into four treatments(n=17 per treatment)from 5 blocks according to milk yield using a randomized complete block design.No initial differences in parity(2.13±1.21),days in milk(165±21 d),and milk yield(33.93±3.81 kg/d)between groups.Cows were fed the basal diet sup-plemented with 0,2,4,or 8 g/kg red clover extract(RCE)in diet(dry matter based).Feeding,refusal feed weights,and milk yield were recorded three consecutive days in weeks 0,4,8,and 12.Blood was collected from the tail vein of the cows on the last day of weeks 4,8 and 12,1 h after the morning feeding,and analyzed for hormones,immunoglobulins,inflammatory markers,and markers of liver and kidney activities.The dry matter intake was significantly decreased by 3.7％in the 8 g/kg group(P＜0.05).The fat-corrected milk yield was significantly higher in both of the 2 and 4 g/kg groups(P＜0.01).Plasma estradiol and prolactin showed a quadratic effect with increasing RCE levels,with the highest in the 4 g/kg group(P＜0.05).Plasma tumor necrosis factor(TNF)-a,interleukin(IL)-6,and IL-1β levels decreased linearly with increasing dietary RCE levels.Plasma IL-18 levels showed a quadratic effect with increasing dietary RCE levels,with significantly lower levels in both of the 2 and 4 g/kg groups(P＜0.05).Plasma immunoglobulin A and D-lactic acid levels showed a quadratic effect with increasing dietary RCE levels,with significantly higher level in the 4 g/kg group(P＜0.05).The liver function and kidney activity makers were similar(P＞0.05).These results recommend the supplementation of RCE at a level from 2 to 4 g/kg DM.

Dairy cowRed clover isoflavoneImmunityAnti-inflammatory

Shiqi Zhang、Xiaoyin Zhang、Zhanbo Xiong、Kexin Li、Yuan Gao、Ying Bu、Nan Zheng、Shengguo Zhao、Jiaqi Wang

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State Key Laboratory of Animal Nutrition,Institute of Animal Sciences,Chinese Academy of Agricultural Sciences,Beijing 100193,China

National Key R&D Program of ChinaModern Agro-Industry Technology Research System of ChinaState Key Laboratory of Animal NutritionKey Program of Inner Mongolia

2022YFD1301000CARS-362004DA125184G21082021-NDTIC-2

2024

10.1016/j.aninu.2023.12.005

动物营养(英文)

动物营养(英文)

CSTPCD
ISSN：
年,卷(期)：2024.16(1)
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