首页|Development of small intestinal barrier function and underlying mechanism in Chinese indigenous and Duroc piglets during suckling and weaning periods

Development of small intestinal barrier function and underlying mechanism in Chinese indigenous and Duroc piglets during suckling and weaning periods

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
This study explored the developmental changes in small intestinal barrier function and the potential regulatory roles of intestinal microbiota and metabolites in different breeds of piglets during suckling and weaning periods.Taoyuan black(TB),Xiangcun black(XB),and Duroc(DR)piglets(10 litters per breed;half male and half female)were selected for sampling to evaluate the intestinal barrier-related indexes and intestinal microbiota and metabolites at 1,10,21(weaned),and 24(3 d after weaning)d old.The results showed that weaning led to severe shedding of small intestinal microvilli and sparse microvilli arrangement.D-lactate level in the ileum of TB and XB piglets during suckling and weaning periods was lower(P＜0.01)than that of DR piglets,as well as the ileal diamine oxidase level at 1 d old.The expression level of mucin 1 was higher(P＜0.05)in the ileum of TB and XB piglets than that of DR piglets,and it was the highest in the ileum of TB piglets at 21 d old.The expression levels of mucin 2 and mucin 13 were higher(P＜0.10)in TB and XB piglets than those of DR piglets at 21 d old,whereas mucin 2 and mucin 13 in the ileum of TB and XB piglets were higher(P＜0.05)than those of DR piglets at 24 d old.TB and XB piglets had a lower relative abundance of Escherichia_Shigella at 21 and 24 d old,but they had higher Streptococcus at 1 and 24 d old than DR piglets(P＜0.01).Differential metabolites between the three breeds of piglets were mainly related to oxidative phosphorylation,steroid biosynthesis,and bile acid synthesis.Collectively,these findings suggest that different pig breeds present differences in the development of the small intestinal barrier function.Compared with DR piglets,TB and XB piglets had higher intestinal permeability during the suckling period and a stronger intestinal mechanical barrier after weaning.Moreover,intestinal microbiota and metabolites are the key factors for developing small intestinal barrier functions in different breeds of piglets.

Chinese indigenous pigletDuroc pigletImmune functionIntestinal barrier functionWeaning stress

Sujuan Ding、Yating Cheng、Md Abul Kalam Azad、Qian Zhu、Pan Huang、Xiangfeng Kong

展开 >

CAS Key Laboratory of Agro-ecological Processes in Subtropical Region,Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha 410125,China

College of Advanced Agricultural Sciences,University of Chinese Academy of Sciences,Beijing 100049,China

Key Project of Regional Innovation and Development Joint Fund of National Natural Science Foundation of ChinaYouth Foundation of Guangxi Natural Science FoundationOpen Foundation of the Key Laboratory of Agro-Ecological Processes in Subtropical Region of Chinese Academy of SciencesSpecial Funds for Construction of Innovative Provinces in Hunan Province

U20A20562021JJB130431ISA20221052019RS3022

2024

10.1016/j.aninu.2023.09.005

动物营养(英文)

动物营养(英文)

CSTPCD
ISSN：
年,卷(期)：2024.16(1)
  • 57