Maternal resveratrol improves the intestinal health and weight gain of suckling piglets during high summer temperatures:The involvement of exosome-derived microRNAs and immunoglobin in colostrum

Changming Hong ¹Yujian Huang ²Guan Yang ³Xiaolu Wen ²Li Wang ²Xuefen Yang ²Kaiguo Gao ²Zongyong Jiang ²Hao Xiao²

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作者信息

1. State Key Laboratory of Swine and Poultry Breeding Industry,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China;Key Laboratory of Animal Nutrition and Feed Science in South China,Ministry of Agriculture and Rural Affairs,Guangdong Public Laboratory of Animal Breeding and Nutrition,Guangzhou 510640,China;Guangdong Provincial Key Laboratory of Animal Nutrition Control,Institute of Subtropical Animal Nutrition and Feed,College of Animal Science,South China Agricultural
2. State Key Laboratory of Swine and Poultry Breeding Industry,Institute of Animal Science,Guangdong Academy of Agricultural Sciences,Guangzhou 510640,China;Key Laboratory of Animal Nutrition and Feed Science in South China,Ministry of Agriculture and Rural Affairs,Guangdong Public Laboratory of Animal Breeding and Nutrition,Guangzhou 510640,China
3. Department of Infectious Diseases and Public Health,Jockey Club College of Veterinary Medicine and Life Sciences,City University of Hong Kong,Kowloon 999077,Hong Kong,China
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Abstract

Previous studies have shown that maternal resveratrol improved growth performance and altered the microbial composition of suckling piglets under hot summer conditions.However,it remains unclear how maternal resveratrol improves growth performance of suckling piglets during high summer tem-peratures.A total of 20 sows(Landrace × Large White;three parity)were randomly assigned to 2 groups(with or without 300 mg/kg resveratrol)from d 75 of gestation to d 21 of lactation during high ambient temperatures(from 27 to 30 ℃).The results showed that maternal resveratrol supplementation increased total daily weight gain of piglets under hot summer conditions,which is consistent with previous studies.Furthermore,we found that maternal resveratrol improved the intestinal morphology and intestinal epithelial proliferation in suckling piglets.Dietary resveratrol supplementation affected the characteristics of exosome-derived microRNAs(miRNAs)in sow colostrum,as well as the genes targeted by differentially produced miRNAs.MiRNAs are concentrated in the tight junction pathway.As a result,the expression of intestinal tight junction proteins was increased in suckling piglets(P＜0.05).Notably,maternal resveratrol increased the intestinal secretory immunoglobulin A(sIgA)levels of suckling piglets via colostrum immunoglobin(P＜0.05),which could increase the abundance of bene-ficial microbiota to further increase the concentration of short chain fatty acids(SCFA)in suckling piglets'intestine(P＜0.05).Finally,our correlation analysis further demonstrated the positive associations be-tween significantly differential intestinal microbiota,intestinal sIgA production and SCFA concentrations,as well as the positive relation between total daily weight gain and intestinal health of suckling piglets.Taken together,our findings suggested that maternal resveratrol could promote intestinal health to improve piglet growth during high summer temperatures,which might be associated with the immu-noglobin and exosome-derived miRNAs in sows'colostrum.

Key words

Colostrum/Exosome/Immunoglobulin/Intestinal health/Resveratrol

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基金项目

special fund for Scientific Innovation Strategy-Construction of High-Level Academy of Agriculture Science(R2020PY-JG009)

special fund for Scientific Innovation Strategy-Construction of High-Level Academy of Agriculture Science(R2022PY-QY007)

special fund for Scientific Innovation Strategy-Construction of High-Level Academy of Agriculture Science(202106TD)

China Agriculture Research System(CARS-35)

Project of Swine Innovation Team in Guangdong Modern Agricultural Research System,China(2022KJ126)

出版年

2024

动物营养(英文)

CSTPCD

ISSN：

段落导航