Tryptophan metabolism and piglet diarrhea:Where we stand and the challenges ahead

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外文摘要：The intestinal architecture of piglets is vulnerable to disruption during weaning transition and leads to diarrhea,frequently accompanied by inflammation and metabolic disturbances(including amino acid metabolism).Tryptophan(Trp)plays an essential role in orchestrating intestinal immune tolerance through its metabolism via the kynurenine,5-hydroxytryptamine,or indole pathways,which could be dictated by the gut microbiota either directly or indirectly.Emerging evidence suggests a strong asso-ciation between piglet diarrhea and Trp metabolism.Here we aim to summarize the intricate balance of microbiota-host crosstalk by analyzing alterations in both the host and microbial pathways of Trp and discuss how Trp metabolism may affect piglet diarrhea.Overall,this review could provide valuable in-sights to explore effective strategies for managing piglet diarrhea and the related challenges.

外文关键词：

Tryptophan metabolismPigletDiarrheaIntestinal microbiotaInflammatory response

作者：

Xuan Zhao、Jiaman Pang、Wanghong Zhang、Xie Peng、Zhenguo Yang、Guangdong Bai、Yaoyao Xia

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作者单位：

College of Animal Science and Technology,Southwest University,Chongqing 400715,China

Yunnan Vocational College of Agriculture,Kunming 650211,China

基金：

National Key Research &Development Program of ChinaFundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central UniversitiesNatural Science Foundation of Chongqing

项目编号：

2023YFF1001900SWU-KR24023SWU-KQ23012CSTB2023NSCQ-MSX0786

出版年：

2024

DOI：

10.1016/j.aninu.2024.03.005

动物营养(英文)

CSTPCD

ISSN：

年,卷(期)：2024.17(2)