Abstract
The intestinal architecture of piglets is vulnerable to disruption during weaning transition and leads to diarrhea,frequently accompanied by inflammation and metabolic disturbances(including amino acid metabolism).Tryptophan(Trp)plays an essential role in orchestrating intestinal immune tolerance through its metabolism via the kynurenine,5-hydroxytryptamine,or indole pathways,which could be dictated by the gut microbiota either directly or indirectly.Emerging evidence suggests a strong asso-ciation between piglet diarrhea and Trp metabolism.Here we aim to summarize the intricate balance of microbiota-host crosstalk by analyzing alterations in both the host and microbial pathways of Trp and discuss how Trp metabolism may affect piglet diarrhea.Overall,this review could provide valuable in-sights to explore effective strategies for managing piglet diarrhea and the related challenges.
基金项目
National Key Research &Development Program of China(2023YFF1001900)
Fundamental Research Funds for the Central Universities(SWU-KR24023)
Fundamental Research Funds for the Central Universities(SWU-KQ23012)
Natural Science Foundation of Chongqing(CSTB2023NSCQ-MSX0786)
NETL
NSTL
万方数据