首页|Transcriptome analysis of adipose tissue and muscle of Laiwu and Duroc pigs
Transcriptome analysis of adipose tissue and muscle of Laiwu and Duroc pigs
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Fat content is an important trait in pig production.Adipose tissue and muscle are important sites for fat deposition and affect production efficiency and quality.To regulate the fat content in these tissues,we need to understand the mechanisms behind fat deposition.Laiwu pigs,a Chinese indigenous breed,have significantly higher fat content in both adipose tissue and muscle than commercial breeds such as Duroc.In this study,we analyzed the transcriptomes in adipose tissue and muscle of 21-d-old Laiwu and Duroc piglets.Results showed that there were 828 and 671 differentially expressed genes(DEG)in subcu-taneous adipose tissue(SAT)and visceral adipose tissue(VAT),respectively.Functional enrichment analysis showed that these DEG were enriched in metabolic pathways,especially carbohydrate and lipid metabolism.Additionally,in the longissimus muscle(LM)and psoas muscle(PM),312 and 335 DEG were identified,demonstrating enrichment in the cell cycle and metabolic pathways.The protein-protein interaction(PPI)networks of these DEG were analyzed and potential hub genes were identified,such as FBP1 and SCD in adipose tissues and RRM2 and GADL1 in muscles.Meanwhile,results showed that there were common DEG between adipose tissue and muscle,such as LDHB,THRSP,and DGAT2.These findings showed that there are significant differences in the transcriptomes of the adipose tissue and muscle between Laiwu and Duroc piglets(P＜0.05),especially in metabolic patterns.This insight serves to advance our comprehensive understanding of metabolic regulation in these tissues and provide tar-gets for fat content regulation.
LaiwuDurocAdiposeMuscleTranscriptomeCarbohydrate and lipid metabolism
Jie Wu、Fangyuan Yu、Zhaoyang Di、Liwen Bian、Jie Yang、Lina Wang、Qingyan Jiang、Yulong Yin、Lin Zhang
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National Engineering Research Center for Breeding Swine Industry,State Key Laboratory of Swine and Poultry Breeding Industry,Guangdong Laboratory of Lingnan Modern Agriculture,Guangdong Provincial Key Laboratory of Animal Nutrition Control,College of Animal Science,South China Agricultural University,Guangzhou,510642,Guangdong,China
Key Laboratory of Agro-Ecological Processes in Subtropical Region,Laboratory of Animal Nutritional Physiology and Metabolic Process,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha,410125,Hunan,China
National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Key R & D Program of China
NETL
NSTL
万方数据
