Abstract
Mastitis affects almost all mammals including humans and dairy cows.In the dairy industry,bovine mastitis is a disease with a persistently high incidence,causing serious losses to the health of cows,the quality of dairy products,and the economy of dairy farms.Although local udder infection caused by the invasion of exogenous pathogens into the mammary gland was considered the main cause of mastitis,evidence has been established and continues to grow,showing that nutrition factors and gastrointestinal microbiome(GM)as well as their metabolites are also involved in the development of mammary in-flammatory response.Suboptimal nutrition is recognized as a risk factor for increased susceptibility to mastitis in cattle,in particular the negative energy balance.The majority of data regarding nutrition and bovine mastitis involves micronutrients.In addition,the dysbiotic GM can directly trigger or aggravate mastitis through entero-mammary gland pathway.The decreased beneficial commensal bacteria,low-ered bacterial diversity,and increased pathogens as well as proinflammatory metabolites are found in both the milk and gastrointestinal tract of mastitic dairy cows.This review discussed the relationship between the nutrition(energy and micronutrient levels)and mastitis,summarized the role of GM and metabolites in regulating mastitis.Meanwhile,several non-antibiotics strategies were provided for the prevention and alleviation of mastitis,including micronutrients,probiotics,short-chain fatty acids,high-fiber diet,inulin,and aryl hydrocarbon receptor.
基金项目
National Key R&D Program of China(2022YFD1301102)
National Key R&D Program of China(2023YFD2000703)
Science and Technology Innovation Project of Institute of Animal Sciences(jccxgcias-09-1)
NETL
NSTL
万方数据