首页|Dietary curcumin alleviates intestinal damage induced by ochratoxin A in juvenile grass carp(Ctenopharyngodon idella):Necroptosis and inflammatory responses
Dietary curcumin alleviates intestinal damage induced by ochratoxin A in juvenile grass carp(Ctenopharyngodon idella):Necroptosis and inflammatory responses
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Ochratoxin A(OTA)is one of the most common pollutants in aquatic feed.As a first line of defense,intestinal barriers could be utilized against OTA in order to prevent disorders.Natural product supple-mentation is one of the most popular strategies to alleviate toxicity induced by mycotoxins,but there is a lack of knowledge about how it functions in the teleost intestine.In this study,720 juvenile grass carp of about 11 g were selected and four treatment groups(control group,OTA group,curcumin[Cur]group,and OTA+Cur group)were set up to conduct a 60-day growth test.After the test,the growth perfor-mance and intestinal health related indexes of grass carp were investigated.The addition of dietary Cur could have the following main results:(1)inhibit absorption and promote efflux transporters mRNA expression,reducing the residuals of OTA,(2)decrease oxidative stress by reducing oxidative damage and enhancing the expression of antioxidant enzymes,(3)promote mitochondrial fusion proteins to inhibit the expression of mitotic proteins and mitochondrial autophagy proteins and enhance mito-chondrial function,(4)reduce necroptosis-related gene expression through inhibiting the tumor necrotic factor receptor-interacting protein kinase/mixed lineage kinase domain-like pathway,(5)reduce the expression of pro-inflammatory factors by inhibiting the Toll-like receptor 4/nuclear factor-κB signaling pathway to alleviate the intestinal inflammatory response.In summary,the results suggested that Cur could alleviate OTA-induced intestinal damage by enhancing antioxidant capacity and mitochondrial function as well as reducing necroptosis and inflammation in the grass carp intestine.This study pro-vided a theoretical basis and production implications for dietary Cur that could improve growth per-formance and alleviate the intestinal damage induced by OTA in fish.
Fish Nutrition and Safety Production University Key Laboratory of Sichuan Province,Sichuan Agricultural University,Chengdu 611130,Sichuan,China
Key Laboratory of Animal Disease-Resistance Nutrition,Ministry of Education,Ministry of Agriculture and Rural Affairs,Key Laboratory of Sichuan Province,Sichuan,611130,China
Earmarked Fund for CARSNational Natural Science Foundation of China for Outstanding Youth Science FoundationYoung Top-Notch Talent Support Program111 project
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