首页|Macleaya cordata extract exhibits some potential as a surrogate antibiotic by improving gastrointestinal epithelial status and humoral response in goats

Macleaya cordata extract exhibits some potential as a surrogate antibiotic by improving gastrointestinal epithelial status and humoral response in goats

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Macleaya cordata extract(MCE)is a potential replacement for antibiotics.In the current study,effects of MCE on the gastrointestinal health and humoral responses of host animals were explored.A total of 30 weanling goats with similar body weight of 9.15±1.36 kg were randomly allocated into three groups(n=10 per group):control group(CON group,fed with a basal diet),antibiotic group(Abx group,fed with the basal diet supplemented with 0.18 g/d vancomycin and 0.36 g/d neomycin),and MCE group(fed with the basal diet supplemented with 5 g/d MCE),for three weeks.Results showed that antibiotic addition decreased the height and area of rumen papillae,ruminal mucosa Toll-like receptor 8(TLR8),interleukin-8(IL-8)and interleukin-1β(IL-1β)gene relative expression levels and microbial diversity,altered the volatile fatty acid(VFA)profile in the rumen,and increased monocytes amount and CD4+T cells percentage in the peripheral blood(P＜0.05)compared to CON group.MCE addition increased the average daily gain,ileal villus height,villus height/crypt depth,and immunoglobulin M(IgM)content in the peripheral blood(P＜0.05)compared to the CON.Additionally,MCE addition decreased the pro-portion of isobutyric acid in the chyme of the ileum(P=0.005)compared to the CON group.These results suggest that antibiotic supplementation may suppress the epithelial state and microbial diversity and fermentation in goats,but stimulate cellular response to maintain the growth performance of goats.MCE administration improved the epithelial state and humoral response to promote the growth per-formance in goats.

Macleaya cordata extractSubstitution of antibioticsHumoral immunityGastrointestinal healthBacterial communityBranch-chain fatty acid

Qiongxian Yan、Xilin Li、Xiaoling Zhou、Wenxun Chen、Xingzhou Tian、Suntorn Wittayakun、Pramote Paengkoum、Zhiliang Tan

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Chinese Academy of Sciences Key Laboratory of Agro-Ecological Processes in Subtropical Region,National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production,Hunan Provincial Key Laboratory of Animal Nutrition & Physiology and Metabolism,Institute of Subtropical Agriculture,The Chinese Academy of Sciences,Changsha 410125,China

College of Animal Science,Tarim University,Alaer 843300,China

Key Laboratory of Animal Genetics,Breeding and Reproduction in the Plateau Mountainous Region,Ministry of Education,College of Animal Science,Guizhou University,Guiyang 550025,China

Faculty of Science and Agricultural Technology,Rajamangala University of Technology Lanna,Lampang 52000,Thailand

School of Animal Technology and Innovation,Institute of Agricultural Technology,Suranaree University of Technology,Nakhon Ratchasima 30000,Thailand

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National Key R&D Program of ChinaChangsha Municipal Natural Science FoundationStrategic Priority Research Program of the Chinese Academy of SciencesNatural Science Foundation of Hunan Province of China

2022YFD1301700kq2208245XDA260403042022JJ10054

2024

10.1016/j.aninu.2024.04.014

动物营养(英文)

动物营养(英文)

CSTPCD
ISSN：
年,卷(期)：2024.18(3)