Pogostemon cablin essential oil as feed additive promotes the repair of the rumen epithelial barrier in heat-stressed beef cattle

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外文摘要：Pogostemon cablin essential oil(PEO),extracted from P.cablin,has anti-oxidant,anti-inflammatory,and anti-stress properties,as well as the ability to improve gastrointestinal digestion.This study aims to evaluate the effects of PEO on the performance,rumen epithelial morphology,and barrier function in heat-stressed beef cattle.Thirty-six male Jingjiang cattle at 18 months old were randomly assigned into four groups and fed a diet containing PEO at 0(control),50,100,or 150 mg/kg in the feed concentrate(n=9).All experimental cattle were fed under high temperature and humidity in summer for 60 days.The results indicated that 50 mg/kg of PEO treatment enhanced the average daily gain of beef cattle compared with the control group(P=0.032).All PEO treatments reduced the diamine oxidase activity(P=0.004)and malondialdehyde content(P=0.008)in serum.In addition,the content of 70 kDa heat shock protein in the 100 mg/kg group was increased,and the activity of glutathione peroxidase and total antioxidant capacity in both 100 mg/kg and 150 mg/kg groups were enhanced compared to the control group(P＜0.05).More importantly,PEO treatment with 50 mg/kg enhanced the mRNA relative ex-pressions of occludin in ruminal epithelia but decreased the mRNA relative expressions of c-Jun N-ter-minal kinase,P38 mitogen-activated protein kinases,caspase-3,Beclin1(P＜0.05),and extremely significant declined the mRNA relative expressions of extracellular regulated protein kinases and ubiquitin-binding protein in contrast to the control group(P＜0.01).These findings indicated that dietary PEO supplementation might be favorable to improve growth performance and repairing damaged rumen epithelium of heat-stressed cattle by down-regulating the mitogen-activated protein kinase signaling pathway.

外文关键词：

Beef cattleHeat stressRumen epithelial barrierPogostemon cablin essential oilGrowth performanceMAPK signaling pathway

作者：

Huan Chen、Mingrui Yang、Xianglong Shang、Hao Chen、Yi Li、Yanjiao Li、Lin Li、Mingren Qu、Xiaozhen Song

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作者单位：

Jiangxi Province Key Laboratory of Animal Nutrition,Engineering Research Center of Feed Development,Jiangxi Agricultural University,Nanchang 330045,China

基金：

National Natural Science Foundation of ChinaCentral guidance for local scientific and technological development funding projects of ChinaChina Agriculture Research System of MOF and MARA

项目编号：

3206076820231 zdf03083CARS-37

出版年：

2024

DOI：

10.1016/j.aninu.2024.06.001

动物营养(英文)

CSTPCD

ISSN：

年,卷(期)：2024.18(3)